What is the mechanism for the fluorine18 radiolabelling of 1chloro3cyanobenzene and why does this type of

Question

What is the mechanism for the fluorine-18 radiolabelling of 1-chloro-3-cyanobenzene and why does this type of

substrate typically only give radiochemical yields of less than 10%?

foron
1070
Mechanism:
18
F
CN
CN
This is
Aromatic nucleophilic
18 F
substitution reaction,
1
CN
c’ is substituted by
18 F .
But due to higher electronegativity of F F is
better leaving group than…
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